The ASTON LyoSentinel uses a non-invasive, multi-channel technique to provide in-situ measurements during a lyophilization process including:
Lyophilization (freeze-drying) is the process by which water is removed from a frozen solution by sublimation. The result is a cake-like material that can be rehydrated easily. The process is used routinely in pharmaceutical and life science manufacturing. Water vapor is removed during primary drying (bulk sublimation) and secondary drying (surface desorption) cycles. Temperatures must be controlled tightly during each cycle and the equipment must be monitored for mechanical stresses and leaks to avoid irreversible product damage.
The ASTON LyoSentinel is ideal for in-situ process control. Detecting contaminants or leaks in real-time enables the operator to correct or abort freeze-drying cycles when problems occur.
Mass spectrometers (MS) are available in various sizes, capabilities and price range and have utility in vastly different applications. MS measures the mass of a molecule after converting the molecule to a gas-phase ion. The instrument imparts an electrical charge to molecules and converts the resultant flux of electrically charged ions into a proportional electrical current that a data system then reads. The data system converts the current to digital information, displaying it as a mass spectrum.
Mass Spectrometry Applications
Atonarp initially has deployed the ASTON Platform as an in-situ metrology product in semiconductor fabrication plants to monitor gases associated with the most advanced manufacturing processes. However, a wide variety of applications for our platform beyond semiconductors creates a large potential market for ASTON for the foreseeable future. Researchers from various disciplines within chemistry, biochemistry, and physics regularly depend on mass spectrometric analysis.
Plasma Ionization Method
Advanced Vacuum Controller (AVC)
Key Benefits for Real-Time Process Control