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ASTON Platform
ATON Platform

Mass Spectrometry

Mass spectrometers are available in various sizes, capabilities, and price ranges and have utility in vastly different applications. Mass spec measures the mass of a molecule after ionizing the molecule to a gas-phase anion. The instrument imparts an electrical charge to molecules and converts the resultant flux of electrically charged ions into a proportional electrical current that a data system then reads. The data system converts the current to digital information, displaying it as a mass spectrum.
Photo of a semiconductoru
A wide variety of applications beyond our initial entry in advanced semiconductor manufacturing creates a large potential market for ASTON for the foreseeable future. Researchers from various disciplines within chemistry, biochemistry, and physics regularly depend on mass spectrometric analysis.
  • Oil and Gas
    Natural fuels are complex mixtures. The value depends on composition and contamination levels. The ASTON platform is well suited for fast, accurate analysis of natural gas samples.
  • Pharmaceutical
    Scientists rely on the specificity, dynamic range, and sensitivity of MS to differentiate closely related metabolites and thus identify and quantify metabolites. Particularly in drug discovery, where compound identification and purity from synthesis and early pharmacokinetics are determined, MS has proved indispensable.
  • Life Science Research
    Biochemists use MS for protein, peptide and oligonucleotide analysis. They monitor enzyme reactions, confirm amino acid sequences, identify proteins, monitor protein-ligand complex formation under physiological conditions.
  • Environment
    Food safety and environmental researchers use MS in water quality studies and to measure pesticide residues in foods.

ASTON Differentiation

HyperQuad Technology

  • The hyperbolic quadrupole sensor provides greater sensitivity, even at high sample rates.
  • 10 parts per billion sensitivity
  • Broad dynamic range, accuracy, repeatability, and stability

Plasma Ionization Method

  • The ASTON μ-Plasma ion source was developed to work in corrosive gas conditions and match a typical preventive maintenance cycle of ~500 RF hours for semiconductor process tools
  • Uniquely, ASTON takes advantage of using the process cleaning gases to clean itself of condensing particles during the normal chamber clean cycles

Advanced Vacuum Controller (AVC)

  • AVC integrates with the process chambers for fast changes in process gases
  • Measures dwell times as low as 1 msec, or up to 1000 data points per second

Multi-Laser Optical Spectroscopy

The ATON System delivers quantitative, lab-quality multiplex panel results in minutes in an easy-to-use point-of-care platform. In contrast to laboratory tests, the ATON System is chemistry-free.

Three advanced lasers deliver ultrafast pulses to the sample inside a cartridge or flow cell and excite the molecules in the sample. Sensors collect scattered light. The software identifies the molecular signatures and calculates the concentrations of each target in the test panel.

Real-time results inform personalized treatment decisions for better outcomes, improved patient satisfaction, and reduced costs.

In vitro diagnostics

Atonarp plans to develop this multi-laser optical spectroscopy technology into a family of point-of-care clinical diagnostic tests and panels. Because the system is chemistry-free, the need for specialized analyzers built for specific technologies are removed. Soon, providers will be able to mix and match tests and panels on one analyzer.

Life Science Research

The ATON System may have application in various fields where non-destructive chemical analysis is required. Whether the goal is qualitative or quantitative data, multi-laser optical spectroscopy can provide key information easily and quickly. The ATON System can be applied to characterize the chemical composition and structure of a sample.

ATON Differentiation
  • Broad menu of tests on a single instrument.
    The ATON System uses molecular profiles rather than chemistry or immunoassay techniques to deliver results. Common assay technologies and sample types can be analyzed on a single instrument. As a result, users can replace multiple analyzers with one versatile platform.
  • Lab-quality performance in minutes.
    Each point-of-care test will be validated against its respective lab reference standard. With the ATON System, healthcare providers will have the benefit of both central lab performance and real-time results.
  • Simple to use.
    The ATON System provides users with visual, step-by-step instructions for and performing the test. Sample preparation is minimal.
  • Seamless connectivity.
    The ATON System will have bi-directional connectivity and self-guided user setup. Users will be able to transfer patient data securely via existing middleware or via cloud services from our Instrument to the electronic medical record or laboratory information system.
ATON Advantages
  • Detailed molecular analysis.
    The ATON System offers detailed sample characterization by probing individual chemical bond vibrations. As a result, the spectrum is information-rich and contains data relating to the specific chemical structure of the material being analyzed. It can be used to fully characterize composition.
  • Non-destructive.
    Analysis with the ATON System is non-contact, non-destructive, and requires no sample preparation. Thus, it is possible to analyze samples or vital forensic evidence and retain the sample for additional analysis by other techniques, if necessary.
  • Suitable for in situ, in vitro, and in vivo analysis.
    Since analysis is a non-contact and non-destructive technique, it is suitable for true in-situ analysis. It can be used to probe chemical reactions within a reaction vessel, without perturbing the reaction in any way. It can be used for in vitro and in vivo analyses, including the analysis of cosmetics on the skin, single-cell characterization for micro-biology, and drug-cell interactions for intelligent drug design.