Molecular Precision

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The Atonarp LyoSentinel is the industry’s first ever quantitative real time miniaturized mass spectrometer and Silicon oil protection module for the lyo process gas detection. Now, you can monitor not only the most minuscule traces of gases, but also the precise quantity of each for optimized process control as well as detect the presence of harmful contaminants. With a rugged Faraday Cup and calibration against the Capacitance Diaphragm Gauge (CDG), the
LyoSentinel operates in high pressure environments without the need for external pumps. Its customizable proprietary software puts precision molecular analysis for Lyo applications at your fingertips.


Monitor primary and secondary end points, silicon oil contamination and in-line vaccum leaks. Purpose-built for Lyophilisation Process Control.


Ensure efciency and compliance with Vaccuum and Transfer Chamber Monitoring, Leak Detection, Atmospheric Pressure Gas Analysis and more.


Quantitatively monitor species of interest to flag potential deviation from set parameters with feedback control to maintain the highest process quality

LyoSentinel: The most durable, accurate, cost-effective and hassle-free Solution for process analytics.

Small and Powerful

Compact, sleek and as small as a toaster, the LyoSentinel can be easily retrofitted onto any Freeze-Dryer. Ideal for process control applications, it’s fitted with our proprietary miniaturized array of micro-quadrupoles along with integrated small turbo and roughing pumps and the Silicon oil detect and protect module.

Get real data in real time

The LyoSentinel delivers highly accurate measurements (sub-1%) due to its innovative electronics and signal processing capability. It performs quantitative molecular scans in less than 10ms, allowing for real-time process control optimization. And, with its cloud-connected software, you can leverage the data analytics for unparalleled process insight.

Optimized high-pressure performance

The LyoSentinel operates at ~3 orders of magnitude higher pressure compared to standard mass spectrometers, thanks to the miniature design of Atonarp’s mass spectrometer with its array of micro-quadrupole rods, enabling high operating pressure compatibility.

Work with molecular precision

Ideal for fast repeatable measurements needed in process control applications, the LyoSentinel spans 6+ decades of concentration dynamic range, down to ppm levels. It is calibrated within the same pressure range against the gold standard Capacitance Diaphragm Gauge (CDG).

Experience unparalleled uptime

With a smart modular design, the LyoSentinel guarantees the industry’s lowest downtime, with easy on-site replacement of consumable parts and in-built usage diagnostics. Few required consumables and low maintenance events translate into a low total cost-of-ownership, and hassle-free operation.

Miniaturized Quadrupole Array Filter enables the LyoSentinel Embedded Mass Spectrometer to operate at higher pressure than conventional mass spectrometers.


408 x 204 x 316 mm


22 Kg


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The LyoSentinel Embedded Mass Spectrometer
16 Poles, 9 Quadrupoles

Miniaturized quadrupole arrays contain smaller rods, and more quadrupoles, than a conventional quadrupole detector.

Traditional MS
4 Poles, 1 Quadrupole

The standard-sized array is unable to operate at high pressure and requires external pumps which are space-consuming.

  LyoSentinel Traditional MS
Quantitative Qualitative / Semi-quant
Directly calibrated against a Gold Standard Indirectly by extrapolation, hence inaccurate and requires frequent calibration
Can diferentiate between isobaric masses: CO2 (m/z = 44 ) vs. Propane (m/z = 44) Yes, via its fragmentation ions fingerprinting algorithm
Silicon Oil Protection
Operating pressure (mTorr)
Resolving capability
Quantitative accuracy (%)
Footprint (mm) including pumps
Pumping system
Calibration / tuning
21 CFR Part 11
Cost of ownership (P+M/1yr)